Neurobiology of Disease Dissociation of Metabolic and Neurovascular Responses to Levodopa in the Treatment of Parkinson’s Disease
نویسندگان
چکیده
Shigeki Hirano,1 Kotaro Asanuma,1,2 Yilong Ma,1,3 Chengke Tang,1 Andrew Feigin,1,3 Vijay Dhawan,1,3 Maren Carbon,1,3 and David Eidelberg1,3 1The Feinstein Institute for Medical Research, Manhasset, New York 11030, 2Department of Neurology, Tokushima University Hospital, Tokushima 770-8503, Japan, and 3Departments of Neurology and Medicine, North Shore University Hospital and New York University School of Medicine, New York, New York 10016
منابع مشابه
Betaine protects cerebellum from oxidative stress following levodopa and benserazide administration in rats
Objective(s): The aim of the present study was to evaluate antioxidant and methyl donor effects of betaine in cerebellum following levodopa and benserazide administration in rats. Materials and Methods: Sprague-Dawley male rats were treated with levodopa (LD), betaine (Bet), levodopa plus betaine (LD/Bet), levodopa plus benserazide (LD/Ben), levodopa plus betaine-benserazide (LD/Bet-Ben), and t...
متن کاملDiabetes Increases the Incidence of Levodopa-Induced Dyskinesia in Parkinson’s Disease; A Case-Control Study
Background and Objective: Dyskinesia is a debilitating complication of Parkinsonchr('39')s disease (PD), which appears due to some known risk factors. The effect of diabetes and high plasma glucose on the manifestation of dyskinesia has been evaluated in just a few previous reports. The current study aimed to assess the mentioned correlation. Materials and Methods: In this case-control study, ...
متن کاملاثرات حفاظت کبدی بتائین در مقابل استرس اکسیداتیو ناشی از لوودوپا و بنسرازید در موشهای صحرایی
Introduction: Betaine has been demonstrated to have methyl donor and antioxidant properties in our previous reports. Thus, the aim of the present study was to determine plasma homocysteine concentration and evaluate antioxidant activity of betaine following levodopa and benserazide administration, which routinely are used in treatment of Parkinson’s disease in liver of rats. Methods: Sprague–...
متن کاملDissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease.
We compared the metabolic and neurovascular effects of levodopa (LD) therapy for Parkinson's disease (PD). Eleven PD patients were scanned with both [15O]-H2O and [18F]-fluorodeoxyglucose positron emission tomography in the unmedicated state and during intravenous LD infusion. Images were used to quantify LD-mediated changes in the expression of motor- and cognition-related PD covariance patter...
متن کاملDissimilar mechanistic background of peripheral and orofacial hyperkinesia in patients with Parkinson’s disease and levodopa-induced dyskinesia
Introduction: Long-term levodopa treatment of Parkinson’s disease (PD) is frequently complicated by spontaneously occurring involuntary muscle movements called dyskinesia. The exact pathological mechanism of this complication has not yet been elucidated. We have previously demonstrated that in PD patients the vulnerability to develop peripheral but not orofacial dyskinesia is associated w...
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